Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

As Amylyx prepares for future commercialization, we are building the inventory and cost accounting capabilities needed to support a scalable, compliant, and system-enabled operating model. The Director, Inventory & Cost Accounting will serve as the leader and subject matter expert for inventory & cost accounting, cost of sales, standard costing, inventory valuation, and related U.S. GAAP requirements.

This role will be responsible for leading the buildout of the inventory and cost accounting function, including processes, policies, controls, documentation, reporting, and NetSuite-enabled workflows. The Director will partner closely with Supply Chain, Quality, FP&A, IT, external manufacturing partners, external & internal auditors, and the broader Finance organization to ensure inventory and cost of sales are accurately captured, analyzed, controlled, and reported as Amylyx advances toward commercial launch.

Reporting to the Sr. Director, Corporate Accounting, this position requires a hands-on, systems-oriented accounting leader with deep cost accounting expertise, strong business judgment, and the ability to build scalable practices in a dynamic, evolving environment.

We anticipate hiring the Director, Inventory & Cost Accounting in September 2026.

Responsibilities

Lead the buildout of Amylyx’s inventory and cost of sales accounting function, including scalable processes, policies, controls, documentation, and close procedures.
Develop and manage complete and accurate standard costs, partner with FP&A to build cost of sales budgets and forecasts, manage related variance analyses, and ensure inventory and cost of sales are appropriately capitalized and valued in accordance with U.S. GAAP.
Serve as the company’s subject matter expert for inventory accounting, standard costing, cost of sales, valuation, capitalization, reserves, purchase price and production variances, and related U.S. GAAP matters.
Own the design, implementation, and optimization of inventory and cost accounting processes in NetSuite, partnering with IT, Finance, Supply Chain, Quality, and external partners.
Oversee monthly and quarterly inventory and cost of sales close activities, including reconciliations, journal entries, financial flux analyses, purchase price and production variance analysis, management reporting, and support for SEC reporting and financial statement disclosures.
Partner with Supply Chain, FP&A, and outsourced manufacturing partners to understand manufacturing activity, inventory movements, cost drivers, and operational impacts of purchase price and production variances.
Provide accounting leadership for third-party manufacturing arrangements, including inventory ownership determinations, inventory capitalization, costing methodologies, reserve assessments, and related contractual accounting considerations.
Establish and maintain SOX-compliant controls and audit-ready documentation for inventory and cost of sales ensuring operational effectiveness and readiness for internal and external audits.
Build strong cross-functional relationships and influence across Finance, Supply Chain, IT, Quality, external manufacturing partners, and other key stakeholders.
Direct annual physical inventory count programs, reconciliation activities, and related control processes across third-party inventory locations.
Assess organizational needs and develop the inventory and cost accounting function, including recruitment, training, and development of future team members as the business scales.
Support commercialization readiness activities, including new product launches, manufacturing network expansion, inventory build strategies, and related accounting implications.
Undertake special projects and strategic initiatives as needed.

Required Qualifications

Bachelor’s degree in Accounting, Finance, Business, or related field.
10+ years of progressive accounting experience, including significant inventory and cost accounting experience in manufacturing, biotech, pharmaceutical or life sciences.
Demonstrated experience building, implementing, or improving inventory and cost accounting processes in a commercial public company environment, with an understanding of the rigor required for quarterly close, audit support, and external reporting.
Strong technical knowledge of U.S. GAAP related to inventory and cost of sales.
Strong ERP including inventory costing methodologies, inventory transactions, manufacturing accounting workflows, system implementations, and process optimization initiatives.
Experience with inventory and cost of sales close activities, audit support, external reporting, and SOX-compliant controls in a public company environment.
Experience working with contract manufacturing organizations (CMOs), contract development and manufacturing organizations (CDMOs), and global supply chain networks.
Strong understanding of supply chain operations, inventory movements, standard cost development, purchase price and production variances, and cost of sales forecasting.
3-5 years of supervisory experience directly managing, developing, and coaching team members, including setting priorities, providing feedback, and supporting professional growth.
Proven ability to lead through ambiguity, manage multiple priorities, influence cross-functional stakeholders, and build scalable solutions in a fast-paced environment.
Ability to work independently, exercise sound judgement, and develop efficient business solutions.
Ability and willingness to travel occasionally and periodically conduct business during non-standard hours to support global partners and business needs.

Preferred Requirements

CPA and/or MBA preferred.
Prior biotechnology, pharmaceutical, or life sciences commercialization experience, including support for commercial product launches, inventory build activities, and outsourced manufacturing operations.
Experience with NetSuite ERP and managing global inventory flows and complex third-party manufacturing networks.

Work Location and Conditions

At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.